https://www.nature.com/articles/s41418-017-0040-0
Mammalian endoreplication emerges to reveal a potential developmental timer
- Cell Death & Differentiation (2018)
- doi:10.1038/s41418-017-0040-0
- Published online:
Abstract
Among
the most intriguing and relevant questions in physiology is how
developing tissues correctly coordinate proliferation with
differentiation. Endoreplication, in a broad sense, is a consequence of a
cell division block in the presence of an active cell cycle, and it
typically occurs as cells differentiate terminally to fulfill a
specialised function. Until recently, endoreplication was thought to be a
rare variation of the cell cycle in mammals, more common in
invertebrates and plants. However, in the last years, endoreplication
has been uncovered in various tissues in mammalian organisms, including
human. A recent report showing that cells in the mammary gland become
binucleate at lactation sheds new insight into the importance of
mammalian polyploidisation. We here propose that endoreplication is a
widespread phenomenon in mammalian developing tissues that results from
an automatic, robust and simple self-limiting mechanism coordinating
cell multiplication with differentiation. This mechanism might act as a
developmental timer. The model has implications for homeostasis control
and carcinogenesis.
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