BORIS accumulates in keratinocytes upon mitosis failure. It might therefore be involved in genomic instability by participating in the coordination between S phase (DNA replication, centrosome duplication) and Mitosis (DNA replication and RNA transcription arrest and chromosome condensation).
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Human epidermal keratinocytes treated with an AURORA B KINASE inhibitor that blocks mitosis. Green is centrosome marker gamma-tubulin, red is BORIS, blue is Dapi for the chromosomal DNA. Note the abnormal metaphase figures or nuclei caused by AURB inhibition. |
