RECENT PUBLICATIONS
> Rodríguez et al, Scientific Reports
Allergenicity to worldwide invasive grass Cortaderia selloana as environmental risk to public health
2021
doi.org/10.1038/s41598-021-03581-5
> De Pedro et al, Oncogene
2020
doi: 10.1038/s41388-020-01520-8
doi: 10.1038/s41388-020-01520-8
> Molinuevo et al, Journal of Cell Biology
2020
The DNA damage response links human squamous proliferation with differentiation.
doi: 10.1083/jcb.202001063
> Sanz-Gómez et al, Cell Death and Differentiation
2020
doi: 10.1038/s41418-020-0515-2
> Freije A et al. Methods Mol Biol.
Genetic
Modification of Human Primary Keratinocytes by Lentiviral Vectors.
2019 May 24.
> Sanz-Gómez et
al. Methods Mol Biol.
Keratinocyte
Differentiation by Flow Cytometry.
2019 May 24.
> Gandarillas et al. Cell Cycle.
Polyploidy
and the mitosis path to epidermal cell fate.
2019 Feb;18(3):359-362.
> Mollinedo et al. Scientific Reports
Cellular and
animal models of skin alterations in the autism-related ADNP syndrome.
2019 Jan 24;9(1):736.
> Sanz-Gómez et
al. Head and Neck.
Response of
head and neck epithelial cells to a DNA damage-differentiation checkpoint
involving polyploidization.
2018 Nov;40(11):2487-2497.
> de Pedro et al. Cell Death Disease.
Sublethal UV
irradiation induces squamous differentiation via a p53-independent, DNA
damage-mitosis checkpoint.
2018 Oct 25;9(11):1094.
> Álvarez-Teijeiro et al. Cancers.
Factors
Secreted by Cancer-Associated Fibroblasts that Sustain Cancer Stem Properties
in Head and Neck Squamous Carcinoma Cells as Potential Therapeutic Targets.
2018 Sep 17;10(9).
pii: E334.
> Gandarillas et al. Cell Death Differentiation.
Mammalian endoreplication
emerges to reveal a potential developmental timer.
2018
Mar;25(3):471-476.
> Alonso-Lecue et al. Cell Death Disease.
Inefficient differentiation
response to cell cycle stress leads to genomic instability and malignant
progression of squamous carcinoma cells.
2017 Jun
29;8(6):e2901.
> Purba et al. Eur J Cell Biology.
Characterisation of cell cycle
arrest and terminal differentiation in a maximally proliferative human
epithelial tissue: Lessons from the human hair follicle matrix.
2017 Sep;96(6):632-641.
FOXM1 allows human
keratinocytes to bypass the oncogene-induced differentiation checkpoint in
response to gain of MYC or loss of p53.
2017 Feb 16;36(7):956-965.
> Stoll et al, 2016. J
Invest Dermatol.
Membrane-Tethered Intracellular Domain of Amphiregulin Promotes
Keratinocyte Proliferation.
2016 Feb;136(2):444-52.
> Stoll et al, 2016. Oncogene.
The EGF receptor ligand amphiregulin controls cell division via FoxM1.
2016 Apr
21;35(16):2075-86.
> Gandarillas et al. Mol Cell Oncol.
The mitosis-differentiation checkpoint, another guardian of the epidermal
genome.
2015 Jan 21;2(3):e997127.
> Freije et al. Cell Reports.
Inactivation of p53 in
Human Keratinocytes Leads to Squamous Differentiation and Shedding via
Replication Stress and Mitotic Slippage.
2014
Nov 20; 9(4):1349-60.
>
Purba et al. Bioessays.
Human epithelial hair follicle
stem cells and their progeny: Current state of knowledge, the widening gap in
translational research and future challenges.
2014 May;36(5):513-25.
> Gandarillas et al. Experimental
Dermatology.
Cycling up the epidermis:
reconciling 100 years of debate.
2014
Feb;23(2):87-91.
MOST RELEVANT PREVIOUS PUBLICATIONS
> Moumen et al. Mol Cancer.
Myc is required for
beta-catenin-mediated mammary stem cell amplification and tumorigenesis.
2013
Oct 30;12(1):132.
> Toll A et al. J Dermatol
Sci.
Epithelial to mesenchymal
transition markers are associated with an increased metastatic risk in primary
cutaneous squamous cell carcinomas but are attenuated in lymph node metastases.
2013
Nov;72(2):93-102.
>
Gandarillas. Cell Cycle.
The mysterious human epidermal
cell cycle, or an oncogene-induced differentiation checkpoint.
2012
Dec 15;11(24):4507-16.
> Rosa-Garrido et al. PLoS ONE.
A Cell Cycle Role for the
Epigenetic Factor CTCF-L/BORIS.
2012 Jun;7(6):e39371.
>
Toll et al. J Am Acad Dermatology.
D2-40 immunohistochemical
overexpression in cutaneous squamous cell carcinomas: A marker of metastatic
risk.
2012
Dec;67(6):1310-8.
>
Moumen et al. Stem Cells.
The Proto-Oncogene Myc is
Essential for Mammary Stem Cell Function.
2012 Jun;30(6):1246-54.
>
Freije et al. Oncogene.
Cyclin E drives human
keratinocyte growth into differentiation.
2012
Dec 13;31(50):5180-92.
> Muñoz-Alonso et al. J Cell Physiol.
MYC accelerates p21CIP-induced
megakaryocytic differentiation involving early mitosis arrest in leukemia
cells.
2012 May;227(5):2069-78.
>
Zanet J et al. PLOS ONE.
A mitosis block links active
cell cycle with human epidermal differentiation and results in endoreplication.
2010 Dec 20;5(12):e15701.
>
Zanet et al. J Cell Sci. Epidermal.
Endogenous Myc controls
mammalian epidermal cell size, hyperproliferation, endoreplication and stem
cell amplification.
2005 Apr 15;118(Pt 8):1693-1704.
> Baena et al. Proc Natl Acad Sci U S A.
c-Myc regulates cell size and
ploidy but is not essential for postnatal proliferation in liver.
2005
May 17;102(20):7286-91.
>
Dazard et al. Oncogene.
Switch
from p53 to MDM2 as differentiating human keratinocytes lose their
proliferative potential and increase in cellular size.
2000
Aug 3;19(33):3693-705.
>
Gandarillas et al. Oncogene.
Normal and c-Myc-promoted
human keratinocyte differentiation both occur via a novel cell cycle involving
cellular growth and endoreplication.
2000 Jul 6;19(29):3278-89.
> Gandarillas. Exp Gerontol.
Epidermal differentiation,
apoptosis, and senescence: common pathways?
2000
Feb;35(1):53-62.
> Gandarillas
et al. Experimental Dermatology.
et al. Experimental Dermatology.
Evidence that apoptosis and
terminal differentiation of epidermal keratinocytes are distinct processes.
1999 Feb;8(1):71-9.
> Gandarillas et al. Genes Dev.
c-Myc promotes differentiation
of human epidermal stem cells.
1997 Nov 1;11(21):2869-82.
> Gandarillas et al. Mol Carcinog.
Induction of PA2.26, a
cell-surface antigen expressed by active fibroblasts, in mouse epidermal
keratinocytes during carcinogenesis.
1997 Sep;20(1):10-8.
