It is unclear how the skin maintains the balance between cell multiplication and shedding in hyperplastic lesions. For instance, how does the skin maintain squamous differentiation in hyperproliferative psoriasis ?
This question minds very much to the skin and to skin cancer. To answer it, we may need changing minds.
We defend and discuss a new Model for cell cycle-driven epidermal homeostasis maintenance in a View Point at Experimental Dermatology, formated final PDF in
http://onlinelibrary.wiley.com/doi/10.1111/exd.12287/pdf
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| Cycling up the epidermis. Cycling may help keratinocytes climb up through the suprabasal layers. Figure 2b. Gandarillas & Freije, Experimental Dermatology, doi/10.1111/exd.12287 |
