NEW WORK IN MOLECULAR AND CELLULAR ONCOLOGY

Molecular & Cellular Oncology

The Mitosis-Differentiation Checkpoint, another Guardian of the Epidermal Genome

DOI: 10.1080/23723556.2014.997127

Alberto Gandarillas^ab*, Rut Molinuevo^a, Ana Freije^a & Pilar Alonso-Lecue^a

• Accepted author version posted online: 21 Jan 2015

ABSTRACT

The role of p53, The Guardian of the Genome, in the skin has remained elusive. We have explored its function in human epidermal cells and demonstrated the importance of a mitosis-differentiation checkpoint to suppress potential precancerous cells. This places epidermal endoreplication as an antioncogenic mechanism face to irreparable genetic alterations.

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Keywords

• DNA damage,
• DNA repair,
• replication stress,
• MDC,
• mitotic slippage,
• OID,
• UV: ultraviolet,
• KO: knock-out,
• MDC: mitosis-differentiation checkpoint,
• OID: oncogene-induced differentiation