FUNCTIONS FOR HUMAN EPIDERMAL ENDOREPLICATION-III

We thought that keratinocytes halted the cell cycle in a quiescent state as they entered differentiation. We have unravelled a model where they continue the cell cycle and DNA replication as they undergo post-mitotic differentiation (Gandarillas and Freije, 2014, http://onlinelibrary.wiley.com/doi/10.1111/exd.12287/abstract).




I-This explains how keratinocytes become larger as they differentiate 
Gandarillas et al, Oncogene, 2000
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0015701).
Zanet et al, 2005
http://jcs.biologists.org/content/118/8/1693.full



II- This explains how epidermis can coordinate proliferation with differentiation upon cell cycle deregulation
Zanet et al, 2010
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0015701
Freije et al, Oncogene, 2012
http://www.nature.com/onc/journal/vaop/ncurrent/abs/onc201222a.html).



III- This explains how the skin protects itself from keratinocytes with irreparable and potentially oncogenic DNA damage. 
It contributes expulsing mutant cells that could give rise to cancer.
Gandarillas, 2012
http://www.tandfonline.com/doi/full/10.4161/cc.22529#.VG2wZDSG914
Freije et al, 2014
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00866-3