Mol Cell Oncol. 2015 Jan 21;2(3):e997127. doi: 10.1080/23723556.2014.997127.
The mitosis-differentiation checkpoint, another guardian of the epidermal genome.
Abstract
The
role of p53, the original "guardian of the genome", in skin has
remained elusive. We have explored p53 function in human epidermal cells
and demonstrated the importance of a mitosis-differentiation checkpoint
to suppress potentially precancerous cells. This model places epidermal
endoreplication as an antioncogenic mechanism in the face of irreparable genetic alterations.
KEYWORDS:
DNA damage; DNA repair; MDC; OID; mitotic slippage; replication stress
