Bioessays. 2014 Mar 25. doi:
10.1002/bies.201300166. [Epub ahead of print]
Human epithelial hair follicle stem cells and their progeny: Current state of knowledge, the widening gap in translational research and future challenges.
Epithelial hair follicle stem cells (eHFSCs) are required to generate,
maintain and renew the continuously cycling hair follicle (HF), supply cells
that produce the keratinized hair shaft and aid in the reepithelialization of
injured skin. Therefore, their study is biologically and clinically important,
from alopecia to carcinogenesis and regenerative medicine. However, human eHFSCs
remain ill defined compared to their murine counterparts, and it is unclear
which murine eHFSC markers really apply to the human HF. We address this by
reviewing current concepts on human eHFSC biology, their immediate progeny and
their molecular markers, focusing on Keratin 15 and 19, CD200, CD34, PHLDA1, and
EpCAM/Ber-EP4. After delineating how human eHFSCs may be selectively targeted
experimentally, we close by defining as yet unmet key challenges in human eHFSC
research. The ultimate goal is to transfer emerging concepts from murine
epithelial stem cell biology to human HF physiology and pathology.
© 2014 WILEY Periodicals, Inc.
© 2014 WILEY Periodicals, Inc.
KEYWORDS:
CD200, CD34, K15, K19, PHLDA1, bulge, human hair follicle stem cells- PMID: 24665045 [PubMed - as supplied by publisher]
