-OPEN ACCESS-
Exp Dermatol. 2014 Feb;23(2):92-93. doi:
10.1111/exd.12305. Epub 2013 Dec 30.
The functional relevance of polyploidization in the skin.
Abstract
Cell proliferation and differentiation are tightly coupled through the
regulation of the cell division cycle. To preserve specific functional
properties in differentiated cells, distinct variants of the basic mitotic cell
cycle are used in various mammalian tissues, leading to the formation of
polyploid cells. In this issue of Experimental Dermatology, Gandarillas and Freije
discuss the evidences for polyploidization in keratinocytes, a process whose
physiological relevance is now becoming evident. A better evaluation of these
unconventional cell cycles is required not only to improve our understanding of
the development and structure of the epidermis but also for future therapies
against skin diseases.
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
KEYWORDS:
cancer therapy, cell cycle, endomitosis, endoreplication, keratinocyte, polyploidy- PMID: 24330335 [PubMed - as supplied by publisher]
